INDUCTION OF ADENOCARCINOMAS IN THE GLANDULAR STOMACH OF BALB/C MICE TREATED WITH N-METHYL-N-NITROSOUREA

被引：42

作者：

TATEMATSU, M ^{[1
]}

OGAWA, K ^{[1
]}

HOSHIYA, T ^{[1
]}

SHICHINO, Y ^{[1
]}

KATO, T ^{[1
]}

IMAIDA, K ^{[1
]}

ITO, N ^{[1
]}

机构：

[1] NAGOYA CITY UNIV,SCH MED,DEPT AGR SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 09期

关键词：

N-METHYL-N-NITROSOUREA; GLANDULAR STOMACH CANCER; MOUSE; METASTASIS;

D O I：

10.1111/j.1349-7006.1992.tb01999.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male 6-week-old BALB/c strain animals (groups 1 and 2) received 10 weekly intragastric intubations of 0.5 mg/mouse of N-methyl-N-nitrosourea. At week 11 the forestomachs were resected in group 1 but not group 2. Although many animals in group 2 died due to development of squamous cell carcinomas in the forestomach, development of cancers in the glandular stomach was quite similar in both groups. Well-differentiated adenocarcinomas in groups 1 and 2 were found at low incidence at week 20, rising to 100% at week 40, with two lesions metastasizing to the lymph nodes. Four poorly differentiated adenocarcinomas and 5 signet ring cell carcinomas were also found in 27 glandular stomach tumor-bearing animals.

引用

页码：915 / 918

页数：4

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