THE BEHAVIORAL-EFFECTS OF SEROTONIN SYNTHESIS INHIBITION AND QUISQUALIC ACID-INDUCED LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARIS IN RATS

被引：13

作者：

JAKALA, P ^{[1
]}

MAZURKIEWICZ, M ^{[1
]}

SIRVIO, J ^{[1
]}

RIEKKINEN, P ^{[1
]}

机构：

[1] UNIV KUOPIO,DEPT PATHOL,SF-70211 KUOPIO,FINLAND

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 05期

关键词：

D O I：

10.1016/0306-3623(93)90361-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. To investigate the role of the cholinergic and serotonergic systems in the regulation of cognitive functions, the effects of concurrent lesioning of nucleus basalis magnocellularis (NB) with quisqualic acid (quis) and inhibition of brain serotonin synthesis by systemic p-chlorophenylalanine (PCPA) treatment on passive avoidance (PA) retention and water maze (WM) spatial navigation performance were studied in rats. 2. Quis NB lesioning induced a marked reduction (-62%) in frontal cortical cholineacetyltransferase activity, impaired retention of PA, and slightly and transiently impaired acquisition of WM spatial navigation. 3. PCPA (400 mg/kg/day x 3, i.p.) treatment depleted frontal cortical concentrations of both serotonin (82% depletion) and its major metabolite 5-HIAA (90% depletion) and slightly affected the noradrenergic and dopaminergic systems. PCPA treatment alone had no effect on WM or PA behavior, but potentiated the PA retention deficit and slightly aggravated the WM deficit in rats subjected to quis NB lesioning. 4. The present results further support the view that serotonergic and NB neurons interact in the regulation of cognitive functions.

引用

页码：1141 / 1148

页数：8

共 37 条

[1] NEW PERSPECTIVES IN BASAL FOREBRAIN ORGANIZATION OF SPECIAL RELEVANCE FOR NEUROPSYCHIATRIC DISORDERS - THE STRIATOPALLIDAL, AMYGDALOID, AND CORTICOPETAL COMPONENTS OF SUBSTANTIA INNOMINATA [J].