SOLID-PHASE SYNTHESIS OF TRYPANOTHIONE DISULFIDE

被引：12

作者：

FAUCHET, V ^{[1
]}

BOUREL, L ^{[1
]}

TARTER, A ^{[1
]}

SERGHERAERT, C ^{[1
]}

机构：

[1] FAC PHARM LILLE,INST PASTEUR,SERV CHIM BIOMOLEC,CNRS,URA 1309,F-59019 LILLE,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80283-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of trypanothione disulfide 1 was performed according to an original solid phase strategy. The key step involves the selective protection of the primary amines of spermidine with tertiobutyldiphenylsilyl chloride followed by coupling the disilyl derivative on a methylchforoformylated polystyrene resin. After deprotection and assembly of the peptidic chain, treatment of the resin with HF, followed by oxidation and purification afforded 1 in 38% yield.

引用

页码：2559 / 2562

页数：4

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