BIOAVAILABILITY OF ALCOHOL - ROLE OF GASTRIC METABOLISM AND ITS INTERACTION WITH OTHER DRUGS

被引：26

作者：

BARAONA, E ^{[1
]}

GENTRY, RT ^{[1
]}

LIEBER, CS ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CTR ALCOHOL RES & TREATMENT,BRONX,NY 10468

来源：

DIGESTIVE DISEASES | 1994年 / 12卷 / 06期

关键词：

FIRST PASS METABOLISM; GASTRIC ALCOHOL DEHYDROGENASE; H-2-RECEPTOR ANTAGONISTS; ASPIRIN;

D O I：

10.1159/000171470

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In most individuals, only part of the imbibed alcohol reaches the systemic blood. With doses relevant to social drinking, this is due mainly to gastric first-pass metabolism of alcohol, which acts as a barrier against toxic alcohol blood levels. The activity of gastric alcohol dehydrogenase can account for a substantial fraction of this metabolism. Fasting, female gender, old age, dilution of alcoholic beverages, chronic alcohol consumption and still undetermined, factors decrease the gastric metabolism of alcohol. Aspirin a:nd some Hz-receptor antagonists also inhibit this gastric activity. In subjects with documented first-pass metabolism, the!je drugs increase blood alcohol levels, especially after repeated small drinks, and may result in unexpected impairment to perform complex tasks, such as driving. Thus, patients treated with these drugs should be warned of this possible side effect.

引用

页码：351 / 367

页数：17