DETERMINATION OF PINDOLOL IN HUMAN SERUM BY HPLC

被引：10

作者：

CHMIELOWIEC, D ^{[1
]}

SCHUSTER, D ^{[1
]}

GENGO, F ^{[1
]}

机构：

[1] MILLARD FILLMORE HOSP,INST DENT NEUROL,DEPT NEUROPHARMACOL,3 GATES CIRCLE,BUFFALO,NY 14209

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1991年 / 29卷 / 01期

关键词：

D O I：

10.1093/chromsci/29.1.37

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for determining pindolol from human serum by high-performance liquid chromatography (HPLC) is presented. Pindolol is extracted into methylene chloride from 1 mL of alkalinized serum with a recovery of 87%. The organic layer is evaporated and the residue is reconstituted in mobile phase for injection into the column. Samples are eluted from a 5-mu-m C18 column (250 x 4.6 mm) with acetonitrile-water containing 0.1% triethylamine, pH adjusted to 3.5 with phosphoric acid (20:80 v/v). Samples as low as 2 ng/mL have been detected.

引用

页码：37 / 39

页数：3

共 5 条

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[5]

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