ALLOMETRIC ANALYSIS OF DOXYCYCLINE PHARMACOKINETIC PARAMETERS

被引：29

作者：

RIOND, JL ^{[1
]}

RIVIERE, JE ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,COLL VET MED,DEPT ANAT PHYSIOL SCI & RADIOL,TOXICOKINET LAB,RALEIGH,NC 27695

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 1990年 / 13卷 / 04期

关键词：

D O I：

10.1111/j.1365-2885.1990.tb00795.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Riond, J.‐L. & Riviere, J.E. Allometric analysis of doxycycline pharmacokinetic parameters. J. vet. Pharmacol. Therap. 13, 404–407. Doxycycline serum concentration‐time profiles and elimination half‐lives in several species were evaluated by allometric techniques. Doxycycline elimination half‐life increased with body weight. Interspecies scaling of total or free doxycycline serum concentration‐time profiles was possible by use of Dedrick plots with the exception of doxycycline total concentrations in cats. The observed difference in cats was attributed to more extensive binding to plasma proteins. Dr Jean‐Luc Riond, Pathophysiologisches Jnstitut, Universität Bern, Murtenstrasse 35, CH‐3010 Bern, Switzerland. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：404 / 407

页数：4

共 20 条

[1] BOCKER R, 1981, ARZNEIMITTEL-FORSCH, V31-2, P2116
[2] INTERSPECIES SCALING, ALLOMETRY, PHYSIOLOGICAL TIME, AND THE GROUND PLAN OF PHARMACOKINETICS
BOXENBAUM, H
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1982, 10 (02): : 201 - 225
[3] DEDRICK RL, 1970, CANCER CHEMOTH REP 1, V54, P95
[4] ANIMAL SCALE-UP
DEDRICK, RL
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1973, 1 (05): : 435 - 460
[5] FOURTILLAN JB, 1980, NOUV PRESSE MED, V2, P77
[6] PHARMACOKINETIC DATA ON DOXYCYCLINE AND ITS DISTRIBUTION IN DIFFERENT BIOLOGICAL-FLUIDS IN FEMALE GOATS
JHA, VK
JAYACHANDRAN, C
SINGH, MK
SINGH, SD
[J]. VETERINARY RESEARCH COMMUNICATIONS, 1989, 13 (01) : 11 - 16
[7] EVIDENCE FOR METABOLIC INERTNESS OF DOXYCYCLINE
NELIS, HJCF
DELEENHEER, AP
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (02) : 226 - 228
[8] PHARMACOKINETICS AND PLASMA STEADY-STATE LEVELS OF DOXYCYCLINE IN UNDERNUTRITION
RAGHURAM, TC
KRISHNASWAMY, K
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 14 (06) : 785 - 789
[9] DETERMINATION OF DOXYCYCLINE IN BOVINE-TISSUES AND BODY-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING PHOTODIODE ARRAY ULTRAVIOLET-VISIBLE DETECTION
RIOND, J
HEDEEN, KM
TYCZKOWSKA, K
RIVIERE, JE
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (01) : 44 - 47
[10] COMPARATIVE PHARMACOKINETICS OF DOXYCYCLINE IN CATS AND DOGS
RIOND, JL
VADEN, SL
RIVIERE, JE
[J]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1990, 13 (04) : 415 - 424

← 1 2 →