RANDOMIZED TRIAL OF EPIRUBICIN ALONE VERSUS 5-FLUOROURACIL, EPIRUBICIN AND MITOMYCIN-C IN LOCALLY ADVANCED AND METASTATIC CARCINOMA OF THE PANCREAS

被引：23

作者：

TOPHAM, C

GLEES, J

RAWSON, NSB

WOODS, EM

COOMBES, RC

机构：

[1] CHARING CROSS HOSP,DEPT MED ONCOL,FULHAM PALACE RD,LONDON W6 8RF,ENGLAND

[2] ST LUKES HOSP,DEPT RADIOTHERAPY,GUILDFORD,ENGLAND

[3] UNIV SASKATCHEWAN,SASKATOON S7N 0W0,SASKATCHEWAN,CANADA

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 64卷 / 01期

关键词：

D O I：

10.1038/bjc.1991.265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sixty-nine unselected patients with locally advanced and metastatic carcinoma of the pancreas, who had not received previous chemotherapy or radiotherapy were randomised to receive either 5-fluorouracil, epirubicin and mitomycin C (FEM) or epirubicin. Survival was not significantly different in the two arms. Toxic reactions (WHO grade > 3) in the FEM and epirubicin arm respectively included nausea (2) (4), severe alopecia (1) (3) and leucopenia (1), (5), none of these were statistically significant. We therefore suggest that combination chemotherapy should not be used in preference to single agent chemotherapy as standard treatment for locally advanced or metastatic cancer of the pancreas.

引用

页码：179 / 181

页数：3

共 5 条

[1] A COMPARISON OF 3 CHEMOTHERAPEUTIC REGIMENS IN THE TREATMENT OF ADVANCED PANCREATIC AND GASTRIC-CARCINOMA - FLUOROURACIL VS FLUOROURACIL AND DOXORUBICIN VS FLUOROURACIL, DOXORUBICIN, AND MITOMYCIN [J].

CULLINAN, SA ;

MOERTEL, CG ;

FLEMING, TR ;

RUBIN, JR ;

KROOK, JE ;

EVERSON, LK ;

WINDSCHITL, HE ;

TWITO, DI ;

MARSCHKE, RF ;

FOLEY, JF ;

PFEIFLE, DM ;

BARLOW, JF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 253 (14) :2061-2067

[2]

GRAY LW, 1973, 7TH NAT CANC C PHIL, P503

[3] PHASE-I-II STUDY OF PROPHYLACTIC HEPATIC IRRADIATION WITH LOCAL IRRADIATION AND SYSTEMIC CHEMOTHERAPY FOR ADENOCARCINOMA OF THE PANCREAS [J].

KOMAKI, R ;

HANSEN, R ;

COX, JD ;

WILSON, JF .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 15 (06) :1447-1452

[4] CURRENT STATUS OF CHEMOTHERAPY FOR ADVANCED PANCREATIC AND GASTRIC-CANCER [J].

OCONNELL, MJ .

JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (07) :1032-1039

[5] PHASE-II STUDY OF EPIRUBICIN IN ADVANCED ADENOCARCINOMA OF THE PANCREAS [J].

WILS, J ;

BLEIBERG, H ;

BLIJHAM, G ;

DALESIO, O ;

DUEZ, N ;

LACAVE, A ;

SPLINTER, T .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1985, 21 (02) :191-194

← 1 →