EFFECT OF A TYROSINE KINASE INHIBITOR, GENISTEIN, ON THE ACTIONS OF PROLACTIN IN CULTURED MOUSE MAMMARY TISSUES

被引：18

作者：

FAN, GA ^{[1
]}

RILLEMA, JA ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PHYSIOL,540 E CANFIELD,DETROIT,MI 48201

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1992年 / 83卷 / 01期

关键词：

GENISTEIN; TYROSINE KINASE; PROLACTIN; MAMMARY GLAND TISSUE;

D O I：

10.1016/0303-7207(92)90194-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genistein, an inhibitor of tyrosine kinase, was used to determine the possible role of tyrosine kinase in the prolactin (PRL) stimulation of milk product formation and ornithine decarboxylase (ODC) activation in cultured mouse mammary gland tissue. Genistein (10-200-mu-M) inhibited in a dose-response fashion the PRL stimulation of casein, lipid and lactose synthesis as well as ODC activation. Genistein, however, did not inhibit the phospholipase C, phorbol myristate acetate or cAMP effects on ODC activation. These results suggest the possible involvement of tyrosine kinase in the mechanism by which PRL expresses its effects in mammary gland tissues.

引用

页码：51 / 55

页数：5

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