HIGH-SENSITIVITY OF PORCINE CEREBRAL-ARTERIES TO ENDOTHELIN

被引：14

作者：

FUKUDA, S

TAGA, K

SHIMOJI, K

机构：

[1] Department of Anesthesiology, Niigata University School of Medicine, Asahimachi, Niigata

来源：

EXPERIENTIA | 1991年 / 47卷 / 05期

关键词：

ENDOTHELIN; PORCINE; CEREBRAL ARTERY; CORONARY ARTERY; RENAL ARTERY;

D O I：

10.1007/BF01959948

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The threshold concentration of endothelin to induce contractions in porcine cerebral arteries (anterior cerebral, Willis ring and basilar artery) was lower than those for coronary and renal arteries. The median effective concentrations (ED50) of endothelin in cerebral arteries were also significantly lower than those for coronary and renal arteries. There was no significant difference in the sensitivity to endothelin among cerebral arteries, or between coronary and renal arteries. The maximal percentage of contractions induced by endothelin, as compared to that induced by 10(-1) M potassium chloride, was not significantly different between the arteries.

引用

页码：475 / 477

页数：3

共 13 条

[1] CEREBRAL ARTERIAL SPASM .1. IN-VITRO CONTRACTILE ACTIVITY OF VASOACTIVE AGENTS ON CANINE BASILAR AND MIDDLE CEREBRAL-ARTERIES [J].