EFFECTS OF DI-N-PROPYLACETATE AN ANTICONVULSIVE COMPOUND ON GABA METABOLISM

被引：451

作者：

GODIN, Y

HEINER, L

MARK, J

MANDEL, P

机构：

[1] Centre de Neurochime, CN.R.S., Institut de Chime Biologique, Faculté de Médecine, Strasbourg

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 06期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb08975.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects on GABA metabolism of an anticonvulsant drug, di‐n‐propylacetate (DPA), were studied. Given intraperitoneally DPA increases the brain GABA content and does not change its biosynthesis from glutamic acid. However, it inhibits in vitro both glutamate decarboxylase and aminobutyrate transaminase (GABA‐T) activities. The inhibition is more pronounced on the GABA‐T and this observation might explain the increase of GABA level. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：869 / &

共 17 条

[1] SUBCELLULAR DISTRIBUTION OF ENZYMES OF GLUTAMATE METABOLISM IN RAT BRAIN [J].