DIFFERENTIAL INTERACTIONS OF RO-15-4513 WITH BENZODIAZEPINES, ETHANOL AND PENTOBARBITAL

被引：7

作者：

DEACON, RMJ

BUDHRAM, P

THOMSON, TA

GARDNER, CR

机构：

[1] Roussel Laboratories Limited, Swindon, Wiltshire SN3 5BZ, Kingfisher Drive, Covingham

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 2-3期

关键词：

(Rat); Barbiturates; Benzodiazepines; Ethanol; Ro; 15-4513;

D O I：

10.1016/0014-2999(90)90311-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of the imidazobenzodiazepine Ro 15-4513 in combination with three CNS depressants (ethanol, benzodiazepine agonists and pentobarbital) were examined in three different experiments. Full antagonism of classical benzodiazepines by Ro 15-4513 was seen in all three situations. Partial antagonism of ethanol occured in the pull up test of muscle relaxation in rats, but not in the inhibition of ultrasounds produced in rat pups by mild stress. The depressant effect of ethanol on twitching of the urethane-anaesthetised rat suprahyoid muscles was reversed. No attenuation of the effects of pentobarbital was seen in any test. © 1990.

引用

页码：283 / 290

页数：8

共 32 条

[1] EFFECTS OF THE IMIDAZOBENZODIAZEPINE R015-4513 ON THE STIMULANT AND DEPRESSANT ACTIONS OF ETHANOL ON SPONTANEOUS LOCOMOTOR-ACTIVITY [J].