SYN-SELECTIVE MICHAEL ADDITION OF LITHIATED 2-ALKOXYACETATES AND 2-ALKOXYACETAMIDES TO ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS

被引：18

作者：

KANEMASA, S ^{[1
]}

NOMURA, M ^{[1
]}

WADA, E ^{[1
]}

机构：

[1] KYUSHU UNIV, INTERDISCIPLINARY GRAD SCH ENGN SCI, DEPT MOLEC SCI & TECHNOL, KASUGA, FUKUOKA 816, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 10期

关键词：

D O I：

10.1246/cl.1991.1735

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The lithium Z-enolates derived from 2-alkoxyacetates and -acetamides undergo unusual syn-selective Michael addition to alpha,beta-unsaturated carbonyl compounds, where the syn selectivity of the amide enolates is much higher than that of the ester enolates. Factors that influence the stereoselectivity are also discussed.

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页码：1735 / 1738

页数：4

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