BOTULINUM TOXIN THERAPY - DISTANT EFFECTS ON NEUROMUSCULAR-TRANSMISSION AND AUTONOMIC NERVOUS-SYSTEM

被引：142

作者：

GIRLANDA, P ^{[1
]}

VITA, G ^{[1
]}

NICOLOSI, C ^{[1
]}

MILONE, S ^{[1
]}

MESSINA, C ^{[1
]}

机构：

[1] UNIV MESSINA,INST NEUROL & NEUROSURG SCI,I-98100 MESSINA,ITALY

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1992年 / 55卷 / 09期

关键词：

D O I：

10.1136/jnnp.55.9.844

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with Bo Tox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuro-muscular transmission and on autonomic function.

引用

页码：844 / 845

页数：2

共 8 条

[1] SINGLE-FIBER ELECTROMYOGRAPHY FOR STUDYING THE EFFECT OF BETAMETHASONE ON NORMAL NEUROMUSCULAR-JUNCTIONS IN MAN [J].