INTERLEUKIN-1 RECEPTOR-TYPE-I MESSENGER-RNA IN MOUSE-BRAIN AS AFFECTED BY PERIPHERAL ADMINISTRATION OF BACTERIAL LIPOPOLYSACCHARIDE

Following administration of endotoxin in vivo, alterations of interleukin-1 (IL-1) receptor binding have been reported. In order to assess in vivo regulation of IL-1 receptor gene expression in brain, mRNA levels for IL-1 receptor type I were measured after peripheral administration of bacterial lipopolysaccharide in mice. When 25 mu g of lipopolysaccharide were administered intraperitoneally, IL-1 receptor type I mRNA in the brain was increased after 3 h. After 20 h, the level was diminished. This result suggests that bacterial lipopolysaccharide affects regulation of IL-1 receptor type I mRNA expression in mouse brain.