ISOXAZOLINE DERIVATIVES AS POTENTIAL INHIBITORS OF THE PROTEOLYTIC-ENZYMES HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G AND PROTEINASE-3 - A STRUCTURE-ACTIVITY RELATIONSHIP STUDY

被引：49

作者：

GROUTAS, WC ^{[1
]}

VENKATARAMAN, R ^{[1
]}

CHONG, LS ^{[1
]}

YODER, JE ^{[1
]}

EPP, JB ^{[1
]}

STANGA, MA ^{[1
]}

KIM, EH ^{[1
]}

机构：

[1] WICHITA STATE UNIV, DEPT CHEM, WICHITA, KS 67260 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 02期

关键词：

D O I：

10.1016/0968-0896(95)00006-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A senes of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3.

引用

页码：125 / 128

页数：4

共 22 条

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