INCREASED ACTIVATION OF 2',3'-DIDEOXYCYTIDINE BY ACTVICIN

被引：3

作者：

AGARWAL, RP ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT MED ONCOL,MIAMI,FL 33136

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of acivicin (ACV) on cell growth, cell cycle progression, and intracellular accumulation of 2',3'-dideoxycytidine (ddC) was examined. Treatment of H9 cells with ACV (1 mu M) plus ddC (25 mu M) for 24 hrs inhibited cell growth to 74 +/- 7%, arrested cells in the S phase, and increased the cellular ddC accumulation to 195-208% of control. The concentrations of ddCTP, the active form of ddC, was increased 3.4 fold in ACV treated cells. (C) 1994 Academic Press, Inc.

引用

页码：1524 / 1529

页数：6

共 20 条

[1] INACTIVATION BY ACIVICIN OF RAT-BRAIN CTP AND GMP SYNTHETASES AND DEPRESSION OF CTP AND GTP CONCENTRATIONS [J].