TETRAETHYLAMMONIUM STIMULATES ADRENOMEDULLARY SECRETION BY CAUSING FLUCTUATIONS IN A CYTOSOLIC FREE CA CONCENTRATION

被引：17

作者：

SORIMACHI, M

YAMAGAMI, K

NISHIMURA, S

机构：

[1] Department of Physiology, Kagoshima University, School of Medicine, Kagoshima

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 02期

关键词：

Adrenal chromaffin cell; Cytosolic free calcium; Fura-2; microfluorimetry; Tetraethylammonium;

D O I：

10.1016/0006-8993(90)90296-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tetraethylammonium (TEA) caused marked fluctuations in a cytosolic free Ca concentration, which was measured by fura-2 microfluorimetry in bovine adrenal chromaffin cells. At the same time, TEA stimulated catecholamine secretion from cat and bovine chromaffin cells. Present results suggest that TEA indirectly increases the Ca2+ influx by depolarizing the cell membrane and consequently stimulates catecholamine secretion. © 1990.

引用

页码：347 / 350

页数：4

共 15 条

[1]

ANTON AH, 1962, J PHARMACOL EXP THER, V138, P360

[2] ACTION POTENTIALS IN RAT CHROMAFFIN CELL AND EFFECTS OF ACETYLCHOLINE [J].