INVOLVEMENT OF CYCLIC AMP-DEPENDENT PROTEIN-KINASES IN THE SIGNAL TRANSDUCTION PATHWAY FOR INTERLEUKIN-1

被引：41

作者：

CHEDID, M ^{[1
]}

MIZEL, SB ^{[1
]}

机构：

[1] WAKE FOREST UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,WINSTON SALEM,NC 27103

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 07期

关键词：

D O I：

10.1128/MCB.10.7.3824

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the κ immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

引用

页码：3824 / 3827

页数：4

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