CEREBELLAR SYNDROME CAUSED BY ISONIAZID

被引：12

作者：

BLUMBERG, EA

GIL, RA

机构：

[1] Division of Infectious Disease, Department of Medicine, Hahnemann University, Philadelphia, PA 19102, Broad and Vine

来源：

DICP-THE ANNALS OF PHARMACOTHERAPY | 1990年 / 24卷 / 09期

关键词：

D O I：

10.1177/106002809002400906

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Treatment of tuberculosis in a hemodialysis patient with isoniazid, rifampin, and pyrazinamide resulted in the development of acute cerebellar dysfunction. This resolved rapidly following the discontinuation of isoniazid and pyrazinamide, reinstitution of isoniazid at a lower dose, and addition of pyridoxine. We discuss why we believe this syndrome was caused by isoniazid. Patients with renal failure who undergo antituberculous therapy with isoniazid should receive supplemental pyridoxine to reduce the likelihood of isoniazid-related neurotoxicity

引用

页码：829 / 831

页数：3

共 14 条

[1] GUIDELINES FOR DRUG-THERAPY IN RENAL-FAILURE [J].

BENNETT, WM ;

SINGER, I ;

GOLPER, T ;

FEIG, P ;

COGGINS, CJ .

ANNALS OF INTERNAL MEDICINE, 1977, 86 (06) :754-783

[2] ISONIAZID DOSAGE IN PATIENTS WITH RENAL-FAILURE [J].

BOWERSOX, DW ;

WINTERBAUER, RH ;

STEWART, GL ;

ORME, B ;

BARRON, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 289 (02) :84-87

[3] AMINO-ACIDS AS CENTRAL NEUROTRANSMITTERS [J].

DEFEUDIS, FV .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1975, 15 :105-130

[4]

GAMMON GD, 1953, AMA ARCH NEUROL PSY, V70, P64

[5]

GIBSON FD, 1966, GERIATRICS, V21, P178

[6] ADVERSE-EFFECTS OF ANTI-TUBERCULOSIS DRUGS [J].

GIRLING, DJ .

DRUGS, 1982, 23 (1-2) :56-74

[7]

Gold C H, 1976, Clin Nephrol, V6, P365

[8] ISONIAZID - REVIEW WITH EMPHASIS ON ADVERSE EFFECTS [J].

GOLDMAN, AL ;

BRAMAN, SS .

CHEST, 1972, 62 (01) :71-&

[9]

OESTREICHER R, 1954, AM REV TUBERC PULM, V70, P504

[10] STUDIES OF IMMEDIATE ADVERSE REACTIONS TO DIFFERENT DOSES OF A SLOW-RELEASE PREPARATION OF ISONIAZID [J].

PARTHASARATHY, R ;

DEVADATTA, S ;

FOX, W ;

KRISHNASWAMI, KV ;

RADHAKRISHNA, S ;

SOMASUNDARAM, PR ;

TRIPATHY, SP .

TUBERCLE, 1976, 57 (02) :115-121

← 1 2 →