PROTEASE DIGESTION OF HEPATITIS-A VIRUS - DISPARATE EFFECTS ON CAPSID PROTEINS, ANTIGENICITY, AND INFECTIVITY

被引：6

作者：

LEMON, SM ^{[1
]}

AMPHLETT, E ^{[1
]}

SANGAR, D ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 10期

关键词：

D O I：

10.1128/JVI.65.10.5636-5640.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

High concentrations of either trypsin or chymotrypsin caused nearly complete cleavage of capsid protein VP2 of hepatitis A virus but did not significantly reduce the infectivity, thermostability, or antigenicity of the virus. Chymotrypsin also had a lesser effect on VP1. These findings indicate the presence of a protease-accessible VP2 surface site which neither contributes significantly to the dominant antigenic site nor plays a role in the attachment of the virus to putative cell receptors.

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页码：5636 / 5640

页数：5

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