PREPARATION AND PURIFICATION OF L-(+/-)-5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID

被引：32

作者：

TEMPLE, C

ELLIOTT, RD

ROSE, JD

MONTGOMERY, JA

机构：

[1] Kettering-Meyer Laboratory, Southern Research Institute, Birmingham

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 06期

关键词：

D O I：

10.1021/jm00192a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reinvestigation of the conversion of folic acid to leucovorin [L-(±)-5-CHO-THF] led to improved methodsfor the synthesis of this drug, which is suitable for clinical use. Also, methods were developed for the chromatographic and nonchromatographic purification of less pure samples of l-(±)-5-CHO-THF. © 1979, American Chemical Society. All rights reserved.

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页码：731 / 734

页数：4

相关论文

共 22 条

[1] MECHANISMS OF FOLATE COFACTORS [J].

BENKOVIC, SJ .

ACCOUNTS OF CHEMICAL RESEARCH, 1978, 11 (08) :314-320

[2] A CONVENIENT METHOD FOR PREPARATION OF DL-5-METHYLTETRAHYDROFOLIC ACID (DL-5-METHYL-5,6,7,8-TETRAHYDROPTEROYL-L-MONOGLUTAMIC ACID) [J].

BLAIR, JA ;

SAUNDERS, KJ .

ANALYTICAL BIOCHEMISTRY, 1970, 34 (02) :376-&

[3] CHEMISTRY OF LEUCOVORIN [J].

COSULICH, DB ;

ROTH, B ;

SMITH, JM ;

HULTQUIST, ME ;

PARKER, RP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (13) :3252-3263

[4] DIASTEREOISOMERS OF LEUCOVORIN [J].

COSULICH, DB ;

SMITH, JM ;

BROQUIST, HP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (16) :4215-4216

[5]

DJERASSI I, 1967, CANCER, V20, P233, DOI 10.1002/1097-0142(1967)20:2<233::AID-CNCR2820200209>3.0.CO

[6]

2-8

[7]

DJERASSI I, 1972, CANCER, V30, P22, DOI 10.1002/1097-0142(197207)30:1<22::AID-CNCR2820300105>3.0.CO

[8]

2-B

[9] A SYNTHETIC COMPOUND WITH FOLINIC ACID ACTIVITY [J].

FLYNN, EH ;

BOND, TJ ;

BARDOS, TJ ;

SHIVE, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (05) :1979-1982

[10] THE PREPARATION OF 2,2,2-TRIFLUOROETHANOL [J].

GILMAN, H ;

JONES, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (03) :1281-1282