A MURINE MODEL FOR THE STUDY OF THE IMPACT OF ASPERGILLUS-FUMIGATUS INOCULATION ON THE FETOPLACENTAL UNIT

被引：9

作者：

JENSEN, HE ^{[1
]}

HAU, J ^{[1
]}

机构：

[1] NATL VET LAB,DK-1503 COPENHAGEN V,DENMARK

来源：

MYCOPATHOLOGIA | 1990年 / 112卷 / 01期

关键词：

aspergillosis; Aspergillus fumigatus; foeto-placental unit; murine model; mycotic abortion;

D O I：

10.1007/BF01795172

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pregnant female BALB/c mice were inoculated intravenously with Aspergillus fumigatus conidia in different concentrations (1×101-1×108) on day 10 of pregnancy. Pregnancy was confirmed by the presence of murine alpha-fetoprotein (m-AFP) in the maternal circulation. Conidia inoculation of 1×103 and greater significantly (p<0.0001) resulted in abortion or placental lesions. Uterine cell infiltrations were recognized in 75% of the mice which aborted following the inoculation of 1×103 conidia or more. In the placental lesions of mice inoculated with 0.5-1×108 conidia, hyphae, haemorrhage, thrombosis, necrosis, calcification, and inflammation were regular findings. Histopathology of other maternal organs revealed that extrauterine organ lesions were closely correlated with the dose of conidia inoculated, and the following pattern of reaction was found: liver > lung > kidney > brain > heart. © 1990 Kluwer Academic Publishers.

引用

页码：11 / 18

页数：8

共 16 条

[1]

CHEMNITZ J, 1982, BIBL ANAT, V22, P87

[2]

CYSEWSKI SJ, 1968, AM J VET RES, V29, P1135

[3]

Emmons C., 1977, MED MYCOLOGY

[4] PLACENTAL AFFINITY FOR PREGNANCY-ASSOCIATED MURINE PROTEIN-1 EXAMINED BY CROSSED AFFINO IMMUNOELECTROPHORESIS [J].