A RARE HLA DQB ALLELE SEQUENCED FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：13

作者：

FRONEK, Z ^{[1
]}

TIMMERMAN, LA ^{[1
]}

MCDEVITT, HO ^{[1
]}

机构：

[1] STANFORD UNIV,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

来源：

HUMAN IMMUNOLOGY | 1991年 / 30卷 / 02期

关键词：

D O I：

10.1016/0198-8859(91)90074-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most autoimmune disorders are associated with particular alleles of the major histocompatibility complex (MHC) class II genes. However, only a minority of individuals with these alleles develop autoimmunity. The identification of alleles more closely associated with an autoimmune disorder such as lupus would facilitate screening and diagnosis and perhaps the understanding of mechanisms of disease. Analysis of sequence variation in the polymorphic first domain of the MHC genes HLA DQ-beta and DQ-alpha has revealed a novel DQ-beta-allele in two Caucasian lupus patients and no Caucasian controls. The novel DQ-beta-allele shares polymorphic amino acids at positions 26 to 30 and 57 with other lupus-associated DQ-beta-alleles. These hypervariable regions may play a role in lupus susceptibility and may provide insights into the molecular mechanism for this susceptibility.

引用

页码：77 / 84

页数：8

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