EVIDENCE FOR ONE-ELECTRON OXIDATION OF BENZYLPENICILLIN G BY LACTOPEROXIDASE COMPOUND-I AND COMPOUND-II

被引：19

作者：

METODIEWA, D ^{[1
]}

DUNFORD, HB ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)92025-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of the widely used antibiotic benzylpenicillin G to undergo a peroxidatic oxidation to produce free radical species has been investigated using conventional spectrophotometry, rapid scan spectrophotometry and an ESR spin trapping technique. Lactoperoxidase was used as a model for a drug oxidizing system. The results of the investigation indicate a normal peroxidatic pathway of benzylpenicillin degradation which leads to superoxide radical generation. © 1990.

引用

页码：1211 / 1216

页数：6

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