INHIBITION OF HUMAN 5-LIPOXYGENASE BY 3-NITRO-2,4,6-TRIHYDROXYBENZAMIDE DERIVATIVES

被引：4

作者：

HONDA, I

NOGUCHI, M

FURUNO, M

MATSUMOTO, T

SHIBAGAKI, M

NOMA, M

YONEYAMA, K

HAYASHI, T

IWAMURA, H

TAKAHASHI, N

YOSHIDA, S

机构：

[1] UTSUNOMIYA UNIV,FAC AGR,WEED CONTROL RES INST,UTSUNOMIYA,TOCHIGI 321,JAPAN

[2] KYOTO UNIV,FAC AGR,DEPT AGR CHEM,SAKYO KU,KYOTO 606,JAPAN

[3] INST PHYS & CHEM RES,WAKO 35101,JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 03期

关键词：

D O I：

10.1080/00021369.1991.10870646

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The inhibitory effects of 3-nitro-2,4,6-trihydroxybenzamide derivatives on human 5-lipoxygenase (5-LO), a key enzyme in arachidonic acid cascades, were examined using 5-LO produced by Escherichia coli. Some of the tested compounds inhibited the conversion of arachidonic acid to 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid (5-HPETE), and in particular the N-phenylbutyl derivative was about 30 times more active (IC50 = 35-mu-M) than caffeic acid (IC50 = 1000-mu-M), a known selective 5-LO inhibitor.

引用

页码：833 / 836

页数：4

共 23 条

[1] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .3. EFFECTS OF IONOPHORE-A23187 [J].