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ESTABLISHMENT AND CHARACTERIZATION OF A NEW HUMAN ESTRADIOL-RECEPTOR-POSITIVE AND PROGESTERONE-RECEPTOR-POSITIVE MAMMARY-CARCINOMA SERIALLY TRANSPLANTABLE IN NUDE-MICE

被引：24
作者：
NAUNDORF, H
FICHTNER, I
BUTTNER, B
FREGE, J
机构：
[1] Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, O-1115
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 119卷 / 01期
关键词：
HUMAN MAMMARY CARCINOMA; ESTRADIOL-RECEPTOR-POSITIVE AND PROGESTERONE-RECEPTOR-POSITIVE; NUDE MICE; ESTABLISHMENT MAMMARY CARCINOMAS;
D O I：
10.1007/BF01209485
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 mug oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies.
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页码：35 / 40
页数：6
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