SYNTHETIC CONVERSION OF BRYOSTATIN-2 TO BRYOSTATIN-1 AND RELATED BRYOPYRANS

被引：17

作者：

PETTIT, GR

SENGUPTA, D

HERALD, CL

SHARKEY, NA

BLUMBERG, PM

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] NCI,LCCTP,MOLEC MECH TUMOR PROMOT SECT,BETHESDA,MD 20892

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1991年 / 69卷 / 05期

关键词：

BRYOSTATIN 2-]1; SELECTIVE CONVERSION; BRYOSTATINS-4; AND; 5; PIVALATES;

D O I：

10.1139/v91-126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bryostatin 2 (1a) has been converted to bryostatin 1 (1e) and bryostatin 12 (1i) by a selective protection and deprotection involving the C-26 hydroxyl group. The new bryostatins 1g, 1k, and 1m were also prepared starting from bryostatin 2. The C-7 substituents of natural bryostatins 4 and 5 were revised from isovalerate --> pivalate employing comparative H-1 and C-13 NMR studies of the semi-synthetic bryostatins 1k and 1m and the natural products.

引用

页码：856 / 860

页数：5

共 30 条

[1]

BLUMBERG PM, 1988, CANCER RES, V48, P1

[2] SECONDARY METABOLITES FROM MARINE BRYOZOANS - A REVIEW [J].