TRANSDERMAL FENTANYL - SEEDING TRIAL IN PATIENTS WITH CHRONIC CANCER PAIN

被引：13

作者：

LEVY, MH

ROSEN, SM

KEDZIERA, P

机构：

[1] Pain Management Center, Fox Chase Cancer Center, Philadelphia, PA

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 1992年 / 7卷 / 03期

关键词：

CANCER PAIN; OPIOID ANALGESIA; TRANSDERMAL FENTANYL;

D O I：

10.1016/0885-3924(92)90054-L

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In this study, 6 patients with pain from advanced cancer were enrolled in a multicenter, open-label seeding trial of transdermal fentanyl. Following equianalgesic dose conversion, transdermal fentanyl patches were applied every 3 days. Mean fentanyl dosage doubled by week 2 and tripled by week 4. Pain control improved in all patients. There were no significant changes in mood, constipation, nausea, sedation, daily activities, or interpersonal relationships from pretrial to posttrial analyses. Following the study period, 5 patients were monitored for a mean total of 55 days with a mean final fentanyl dose of 240-mu-g/hr. As part of a comprehensive cancer pain management program, transdermal fentanyl appears to be safe and effective, and should prove to be a useful addition to currently available opioid analgesics.

引用

页码：S48 / S50

页数：3

共 9 条

[1]

Levy, Pain management in advanced cancer, Semin Oncol, 12, pp. 394-410, (1985)

[2]

Levy, Integration of pain management into comprehensive cancer care, Cancer, 63, pp. 2328-2335, (1989)

[3]

Miser, Narang, Dothage, Young, Sindelar, Miser, Transdermal fentanyl for pain control in patients with cancer, Pain, 37, pp. 15-21, (1989)

[4]

Caplan, Southam, Transdermal drug delivery and its application to pain control, Adv Pain Res Ther, 14, pp. 233-240, (1990)

[5]

Simmons, Payne, Richenbacher, Moran, Southam, TTS (fentanyl) in the management of pain in patients with cancer, Proc Am Soc Oncol, 8, (1989)

[6]

Fishman, Pasternak, Wallenstein, Houde, Holland, Foley, The Memorial Pain Assessment Card: a valid instrument for the evaluation of cancer pain, Cancer, 60, pp. 1151-1158, (1987)

[7]

Schipper, Clinch, McMurray, Levitt, Measuring the quality of life of cancer patients: the Functional Living Index—Cancer: development and validation, J Clin Oncol, 2, pp. 472-483, (1984)

[8]

Varvel, Shafer, Hwang, Coen, Stanski, Absorption characteristics of transdermally administered fentanyl, Anesthesiology, 7, pp. 928-934, (1989)

[9]

Plezia, Kramer, Linford, Hameroff, Transdermal fentanyl: pharmacokinetics and preliminary clinical evaluation, Pharmacotherapy, 9, pp. 2-9, (1989)

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