AXOTOMY INCREASES CNTF RECEPTOR MESSENGER-RNA IN RAT SPINAL-CORD

被引：39

作者：

MATA, M

JIN, CF

FINK, DJ

机构：

[1] VAMC, GRECC, ANN ARBOR, MI 48105 USA

[2] UNIV MICHIGAN, DEPT NEUROL, ANN ARBOR, MI 48105 USA

来源：

BRAIN RESEARCH | 1993年 / 610卷 / 01期

关键词：

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; SCIATIC NERVE; SPINAL CORD; POLYMERASE CHAIN REACTION;

D O I：

10.1016/0006-8993(93)91231-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to study the role of ciliary neurotrophic factor (CNTF) and its receptor (CNTF-R) in the response of spinal cord neurons to axotomy, we measured the levels of CNTF mRNA in nerve and CNTF-R mRNA in spinal cord following transection of sciatic nerve, using reverse transcriptase PCR. We found CNTF mRNA levels in the nerve fell and that CNTF-R mRNA levels in spinal cord increased at both 1 and 7 days following transection.

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页码：162 / 165

页数：4

相关论文

共 23 条

[1] CHOLINERGIC NEURONOTROPIC FACTORS - INTRA-OCULAR DISTRIBUTION OF TROPHIC ACTIVITY FOR CILIARY NEURONS [J].

ADLER, R ;

LANDA, KB ;

MANTHORPE, M ;

VARON, S .

SCIENCE, 1979, 204 (4400) :1434-1436

[2]

ARAKAWA Y, 1990, J NEUROSCI, V10, P3507

[3] PURIFICATION OF THE CHICK EYE CILIARY NEURONOTROPHIC FACTOR [J].

BARBIN, G ;

MANTHORPE, M ;

VARON, S .

JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) :1468-1478

[4] THE RECEPTOR FOR CILIARY NEUROTROPHIC FACTOR [J].

DAVIS, S ;

ALDRICH, TH ;

VALENZUELA, DM ;

WONG, V ;

FURTH, ME ;

SQUINTO, SP ;

YANCOPOULOS, GD .

SCIENCE, 1991, 253 (5015) :59-63

[5] REGULATION OF CILIARY NEUROTROPHIC FACTOR EXPRESSION IN MYELIN-RELATED SCHWANN-CELLS INVIVO [J].

FRIEDMAN, B ;

SCHERER, SS ;

RUDGE, JS ;

HELGREN, M ;

MORRISEY, D ;

MCCLAIN, J ;

WANG, DY ;

WIEGAND, SJ ;

FURTH, ME ;

LINDSAY, RM ;

IP, NY .

NEURON, 1992, 9 (02) :295-305

[6] DIFFERENTIAL REGULATION OF MESSENGER-RNA ENCODING NERVE GROWTH-FACTOR AND ITS RECEPTOR IN RAT SCIATIC-NERVE DURING DEVELOPMENT, DEGENERATION, AND REGENERATION - ROLE OF MACROPHAGES [J].

HEUMANN, R ;

LINDHOLM, D ;

BANDTLOW, C ;

MEYER, M ;

RADEKE, MJ ;

MISKO, TP ;

SHOOTER, E ;

THOENEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8735-8739

[7] CNTF AND LIF ACT ON NEURONAL CELLS VIA SHARED SIGNALING PATHWAYS THAT INVOLVE THE IL-6 SIGNAL TRANSDUCING RECEPTOR COMPONENT GP130 [J].

IP, NY ;

NYE, SH ;

BOULTON, TG ;

DAVIS, S ;

TAGA, T ;

LI, YP ;

BIRREN, SJ ;

YASUKAWA, K ;

KISHIMOTO, T ;

ANDERSON, DJ ;

STAHL, N ;

YANCOPOULOS, GD .

CELL, 1992, 69 (07) :1121-1132

[8] THE ALPHA COMPONENT OF THE CNTF RECEPTOR IS REQUIRED FOR SIGNALING AND DEFINES POTENTIAL CNTF TARGETS IN THE ADULT AND DURING DEVELOPMENT [J].

IP, NY ;

MCCLAIN, J ;

BARREZUETA, NX ;

ALDRICH, TH ;

PAN, L ;

LI, YP ;

WIEGAND, SJ ;

FRIEDMAN, B ;

DAVIS, S ;

YANCOPOULOS, GD .

NEURON, 1993, 10 (01) :89-102

[9]

LIN LFH, 1990, J BIOL CHEM, V265, P8942

[10] PURIFICATION, CLONING, AND EXPRESSION OF CILIARY NEUROTROPHIC FACTOR (CNTF) [J].

LIN, LFH ;

MISMER, D ;

LILE, JD ;

ARMES, LG ;

BUTLER, ET ;

VANNICE, JL ;

COLLINS, F .

SCIENCE, 1989, 246 (4933) :1023-1025