SEVERE HYPODIPLOIDY WITH KARYOTYPE INSTABILITY IN A CASE OF ACUTE MYELOID-LEUKEMIA

被引：8

作者：

BETTS, DR

BAUGH, OHA

GIBBONS, B

机构：

[1] ST BARTHOLOMEWS HOSP,IMPERIAL CANC RES FUND,DEPT MED ONCOL,LONDON,ENGLAND

[2] BROOMFIELD HOSP,DEPT HAEMATOL,CHELMSFORD,ESSEX,ENGLAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 74卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)90014-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present a case of acute myeloid leukemia (AML) in an elderly male. A severe hypodiploid karyotype (chromosome range 29-39) was detected with a large amount of cell-to-cell variation, suggesting that the leukemic cells are primarily characterized by chromosomal loss due to karyotypic instability. Severe hypodiploidy is a rare finding in AML but previous similar cases indicate that it confers a very poor prognosis.

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收藏

页码：147 / 149

页数：3

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