RICIN INDUCES THE PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

被引：48

作者：

LICASTRO, F ^{[1
]}

MORINI, MC ^{[1
]}

BOLOGNESI, A ^{[1
]}

STIRPE, F ^{[1
]}

机构：

[1] UNIV BOLOGNA, DIPARTIMENTO PATOL SPERIMENTALE, VIA S GIACOMO 14, I-40126 BOLOGNA, ITALY

来源：

BIOCHEMICAL JOURNAL | 1993年 / 294卷

关键词：

D O I：

10.1042/bj2940517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ricin induced the release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta by human peripheral-blood mononuclear cells in a dose- and time-dependent manner. The inhibition induced by ricin upon the phytohaemagglutinin (PHA)-driven lymphocyte proliferation was greater in cultures of mononuclear cells than that observed in monocyte-free cultures of lymphocytes, and was decreased after addition of an anti-TNF-alpha antibody to PHA-activated cultures. Low levels of TNF-alpha were detected in plasma from rats poisoned with ricin. These results suggest that ricin induced the release of macrophage-derived cytokines which may have a role in the pathogenesis of ricin toxic effects.

引用

页码：517 / 520

页数：4

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