SPLANCHNIC BLOOD-FLOW CHANGES IN THE PRESENCE OF HEPATIC TUMOR - EVIDENCE OF A HUMORAL MEDIATOR

被引：22

作者：

CARTER, R ^{[1
]}

ANDERSON, JH ^{[1
]}

COOKE, TG ^{[1
]}

BAXTER, JN ^{[1
]}

ANGERSON, WJ ^{[1
]}

机构：

[1] UNIV GLASGOW,GLASGOW ROYAL INFIRM,DEPT SURG,GLASGOW G31 2ER,SCOTLAND

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 69卷 / 06期

关键词：

D O I：

10.1038/bjc.1994.201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN sarcoma) and control rats. The vascular resistance of the segment was significantly greater during perfusion by tumour-bearing animals (91.6 mmHg ml(-1) min, s.e. 21.5, vs 51.7 mmHg ml(-1) min, s.e. 7.4, P<0.05), suggesting that intrahepatic tumour may be associated with a circulating vasoactive agent. A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases.

引用

页码：1025 / 1026

页数：2

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