THE ENDOZEPINE ODN STIMULATES POLYPHOSPHOINOSITIDE METABOLISM IN RAT ASTROCYTES

被引：49

作者：

PATTE, C

VAUDRY, H

DESRUES, L

GANDOLFO, P

STRIJDVEEN, I

LAMACZ, M

TONON, MC

机构：

[1] UNIV ROUEN,INSERM,U413,EUROPEAN INST PEPTIDE RES,CELLULAR & MOLEC NEUROENDOCRINOL LAB,CNRS,UA,F-76821 MONT ST AIGNAN,FRANCE

[2] CATHOLIC UNIV NIJMEGEN,NIJMEGEN INST NEUROSCI,DEPT CELLULAR ANIM PHYSIOL,6525 ED NIJMEGEN,NETHERLANDS

来源：

FEBS LETTERS | 1995年 / 362卷 / 02期

关键词：

ENDOZEPINE; OCTADECANEUROPEPTIDE; POLYPHOSPHOINOSITIDE METABOLISM; GLIAL CELL;

D O I：

10.1016/0014-5793(95)00209-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Astrocytes synthesize a series of peptides called endozepines which act as endogenous ligands of benzodiazepine receptors. The present study demonstrates that the endozepine ODN causes a dose-dependent increase in inositol trisphosphate and a parallel decrease in phosphatidylinositol bisphosphate in cultured rat astrocytes, Pre-incubation of astrocytes with the phospholipase C inhibitor U 73122 or with pertussis toxin totally blocked polyphosphoinositide metabolism. These data show that, in rat astrocytes, ODN stimulates a phospholipase C coupled to a pertussis toxin-sensitive G protein.

引用

页码：106 / 110

页数：5

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