INCREASED NUMBER OF SOMATOSTATIN-IMMUNOREACTIVE NEURONS IN PRIMARY CULTURES OF TRISOMY-16 MOUSE NEOCORTEX

被引：9

作者：

CASERTA, MT

CORSI, P

OSTERGRANITE, ML

COYLE, JT

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,MEYER 4-163,600 N WOLFE ST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21205

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 7卷 / 03期

关键词：

Aneuploidy; Cortex; Gene dosage; Glutamic acid decarboxylase; Somatostatin; Tissue culture;

D O I：

10.1016/0169-328X(90)90037-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gene encoding for pre-presomatostatin is located on chromosome 16 of the mouse. To determine the effect of an extra copy of this gene on somatostatin expression in neurons, primary disaggregated cultures of neocortex prepared from 15 day gestational Trisomy 16 mice and their littermate euploid controls were subjected to immunocytochemical staining for somatostatin, neuropeptide Y and glutamic acid decarboxylase. The results demonstrate a selective and significant increase in the number of somatostatin-immunoreactive neurons. © 1990.

引用

页码：269 / 272

页数：4

共 24 条

[1] SUBSETS OF GABAERGIC NEURONS IN DISSOCIATED CELL-CULTURES OF NEONATAL RAT CEREBRAL-CORTEX SHOW CO-LOCALIZATION WITH SPECIFIC MODULATOR PEPTIDES [J].