SQ-14,225 ATTENUATES THE VASCULAR-RESPONSE TO NOREPINEPHRINE IN THE RAT MESENTERIC-ARTERIES

被引：63

作者：

OKUNO, T

KONDO, K

KONISHI, K

SARUTA, T

KATO, E

机构：

[1] Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 35, Shinanomachi

来源：

LIFE SCIENCES | 1979年 / 25卷 / 15期

关键词：

D O I：

10.1016/0024-3205(79)90401-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

SQ 14, 225, a new angiotensin-converting enzyme inhibitor, attenuated the vascular contraction induced by norepinephrine in the perfused rat mesenteric vascular bed, while SQ 20, 881, an another converting enzyme inhibitor, did not have any effect on the vascular reactivity. Furthermore, this effect of SQ 14, 225 was not altered in the presence of bradykinin or angiotensin II in the perfusate. These results suggest that SQ 14, 225 may have a direct antihypertensive effect which is not mediated by the inhibition of angiotensin-converting enzyme. © 1979.

引用

页码：1343 / 1349

页数：7

共 16 条

[1]

Ondetti, Rubin, Cushman, Science, 196, pp. 441-444, (1977)

[2]

Gavras, Brunner, Turini, Kershaw, Tifft, Cuttelod, Gavras, Vukovich, McKinstry, N. Engl. J. Med., 298, pp. 991-995, (1978)

[3]

Cody, Tarazi, Bravo, Fouad, Cli. Sci. Mol. Med., 55, pp. 453-459, (1978)

[4]

Ferguson, Turini, Brunner, Gavras, Lancet, 1, pp. 775-778, (1977)

[5]

Brunner, Gavras, Waeber, Kershaw, Turini, Vukovich, McKinstry, Gavras, Ann. Intern. Med., 90, pp. 19-23, (1979)

[6]

Brunner, Waeber, Wauters, Turini, McKinstry, Gavras, Lancet, 1, pp. 704-707, (1978)

[7]

Case, Atlas, Laragh, Sealey, Sullivan, McKinstry, Prog. Cardiovas. Dis., 21, pp. 195-206, (1978)

[8]

Bravo, Tarazi, Cir. Res., 43, pp. 27-31, (1978)

[9]

Rubin, Laffan, Kotler, O'Keefe, Demaio, Goldberg, J. Pharmacol. Exp. Ther., 204, pp. 271-280, (1978)

[10]

Murthy, Waldron, Goldberg, Vollmer, European J. Pharmacol., 46, pp. 207-212, (1977)

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