SELECTIVITY OF ACTION OF ALKYLATING AGENTS AND DRUG RESISTANCE .2. A COMPARISON OF EFFECTS OF ALKYLATING DRUGS ON GROWTH INHIBITON AND CELL SIZE IN SENSITIVE AND RESISTANT STRAINS OF YOSHIDA ASCITES SARCOMA

被引：28

作者：

HARRAP, KR

HILL, BT

机构：

[1] Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, S.W.3, Fulham Road

来源：

BRITISH JOURNAL OF CANCER | 1969年 / 23卷 / 01期

关键词：

D O I：

10.1038/bjc.1969.31

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The suitability of the Yoshida ascites sarcoma as an experimental model for comparing the quantitative biological effects elicited by a series of alkylating agents has been examined. Myleran, chlorambucil and melphalan all influence the rate of proliferation and volume of the tumour cells, though the order of biological activity in these respects is the inverse of the order of chemical reactivity. The authors are most grateful to Dr. T. A. Connors and Dr. C. R. Ball for the supply of tumour-bearing animals, and for much helpful advice and discussion. © 1969, The British Empire Cancer Campaign for Research. All rights reserved.

引用

页码：227 / &

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