SEIZURE VS SYNCOPE - MEASURING SERUM CREATINE-KINASE IN THE EMERGENCY DEPARTMENT

被引:36
作者
LIBMAN, MD [1 ]
POTVIN, L [1 ]
COUPAL, L [1 ]
GROVER, SA [1 ]
机构
[1] MONTREAL GEN HOSP,DIV CLIN EPIDEMIOL,1650 CEDAR AVE,MONTREAL H3G 1A4,QUEBEC,CANADA
关键词
CREATINE KINASE; TONIC CLONIC SEIZURES; CONVULSIONS; EMERGENCY DEPARTMENT; LOSS OF CONSCIOUSNESS;
D O I
10.1007/BF02598161
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: To determine the utility of serum creatine kinase measurement for diagnosing generalized tonic-clonic seizures in patients presenting to an emergency department with transient loss of consciousness. Design: Prospective evaluation of a diagnostic parameter. Retrospective data collection with blinded assignment to diagnostic groups. Setting: University teaching hospital. Patients: Sequential sample of 205 patients with transient loss of consciousness. The study group consisted of 96 patients who had creatine kinase measurements in the emergency department. Measurements and main results: An investigator blinded to the results of creatine kinase measurements retrospectively classified events into seizure and nonseizure groups on the basis of clinical presentation, prior history, and follow-up investigations. Mean (+/- SE) creatine kinase level was significantly higher in the seizure group (231.1 +/- 34.8 U/L vs. 70.5 +/- 5.6 U/L, p < 0.001). Elevated creatine kinase had a test specificity of 0.98 (95% CI 0.90-1.00) and a sensitivity of 0.43 (95% CI 0.28-0.59). The discriminating power of creatine kinase elevation was directly related to the time interval between the event and testing (p < 0.0001). Among samples taken more than three hours after the event, test sensitivity was 0.80 (0.52-1.00) and specificity was 0.94 (0.71-1.00). Conclusion: Creatine kinase may be a useful test for evaluating patients with transient loss of consciousness. The test is highly specific for diagnosing generalized seizures in the emergency department. Test sensitivity improves by sampling serum at least three hours after the event.
引用
收藏
页码:408 / 412
页数:5
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