MEASUREMENT OF CLOFIBRIC ACID (CPIB) METABOLITES IN PLASMA OF PATIENTS ON CLOFIBRATE THERAPY

被引：10

作者：

FAED, EM

MCQUEEN, EG

机构：

[1] MRC Toxicology Research Unit, University of Otago Medical School, Dunedin

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 03期

关键词：

assay methods; clofibrate; clofibric acid; plasma clofibric acid metabolite concentrations; renal disease;

D O I：

10.1111/j.1440-1681.1979.tb01248.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The metabolites of clofibric acid [CPIB;2‐(chlorophenoxy)‐2‐methylpropionic acid] are present in the plasma of patients on clofibrate therapy. The highest plasma concentrations of CPIB in metabolite form (up to 51 Mg/ml) were generally found in patients with renal disease. Negligible concentrations (≤2 μg/ml) were found in only seven patients out of thirty‐six studied. 2. The two conjugates of CPIB found in urine were present in plasma. 3. When measuring conjugated CPIB in plasma it is essential to take care in the handling and storage of specimens, and to select an assay method known to be specific for unmetabolized CPIB. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：267 / 273

页数：7

共 16 条

[1]

BRIDGMAN JF, 1972, LANCET, V2, P506

[2] GAS-LIQUID-CHROMATOGRAPHIC DETERMINATION OF P-CHLOROPHENOXYISOBUTYRIC ACID AND ITS COMPARISON TO AN ULTRA-VIOLET METHOD [J].