ANGIOTENSIN CONVERTING ENZYME IN MACROVESSELS AND MICROVESSELS OF THE RAT

被引：10

作者：

JANDELEIT, K

JACKSON, B

PERICH, R

PAXTON, D

JOHNSTON, C

机构：

[1] University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1991年 / 18卷 / 05期

关键词：

ANGIOTENSIN CONVERTING ENZYME; HYPERTENSION; MICROVESSELS; RAT; RENIN-ANGIOTENSIN; ALDOSTERONE SYSTEM;

D O I：

10.1111/j.1440-1681.1991.tb01462.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Angiotensin-converting enzyme (ACE) was measured in the aorta, cerebral and mesenteric microvessels of Wistar-Kyoto rats using a specific radioligand assay. 2. Ligand binding studies revealed a four-fold increase in concentration of ACE in mesenteric microvessels, compared with aorta or brain microvessels. The dissociation constant (K(d)) was similar in all tissues. 3. The effects of oral administration of the ACE inhibitor S9650 on vascular ACE in vivo were measured. 4. S9650 produced a dose-dependent inhibition of vascular ACE from brain and mesenteric microvessels.

引用

页码：353 / 356

页数：4

共 17 条

[1] VASCULAR WALL RENIN IN SPONTANEOUSLY HYPERTENSIVE RATS - POTENTIAL RELEVANCE TO HYPERTENSION MAINTENANCE AND ANTIHYPERTENSIVE EFFECT OF CAPTOPRIL [J].