COGNITIVE DEFICIT CAUSED BY REGIONAL DEPLETION OF DOPAMINE IN PREFRONTAL CORTEX OF RHESUS-MONKEY

被引：1218

作者：

BROZOSKI, TJ ^{[1
]}

BROWN, RM ^{[1
]}

ROSVOLD, HE ^{[1
]}

GOLDMAN, PS ^{[1
]}

机构：

[1] NIMH,NEUROPSYCHOL LAB,BETHESDA,MD 20205

来源：

SCIENCE | 1979年 / 205卷 / 4409期

关键词：

D O I：

10.1126/science.112679

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function. Copyright © 1979 AAAS.

引用

页码：929 / 932

页数：4

共 25 条

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