IMMUNE-RESPONSE GENES HAVE A VARIABLE INFLUENCE ON THE SELECTION OF ANTIGENIC FOREIGN AND SELF DETERMINANTS OF INSULIN

被引：32

作者：

COHEN, IR

TALMON, J

LEVRAM, V

BENNUN, A

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.4066

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the proliferative response of mouse T lymphocytes to determinants on ungulate insulins. The immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. Autosensitization against self determinants was observed under specific conditions. These findings emphasize the variable expression of immune response genes.

引用

页码：4066 / 4070

页数：5

共 23 条

[1]

[Anonymous], 1972, ADV PROTEIN CHEM

[2] IMMUNE-RESPONSE GENE CONTROL OF DETERMINANT SELECTION .1. INTRAMOLECULAR MAPPING OF IMMUNOGENIC SITES ON INSULIN RECOGNIZED BY GUINEA-PIG T AND B CELLS [J].