INVITRO EVALUATION OF SUSTAINED DRUG RELEASE FROM BIODEGRADABLE ELASTOMER

被引:61
作者
WADA, R [1 ]
HYON, SH [1 ]
NAKAMURA, T [1 ]
IKADA, Y [1 ]
机构
[1] KYOTO UNIV,BIOMED ENGN RES CTR,53 KAWAHARA CHO SYOGOIN,SAKYO KU,KYOTO 606,JAPAN
关键词
DL-LACTIDE-E-CAPROLACTONE COPOLYMER; BIODEGRADABLE POLYMER; CISPLATIN; MD-805; SUSTAINED DRUG RELEASE;
D O I
10.1023/A:1015860030772
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Poly(DL-lactic acid) (PLA), poly(epsilon-caprolactone) (PCL), and their copolymers (PLA-CL) with various monomer compositions were synthesized, and their properties as matrix for the sustained release of drugs were evaluated. The copolymerization technique produced very soft films which incorporated the drugs without deterioration of the elastic properties. Cisplatin and MD-805 were loaded in the films by casting the polymer solution containing the drugs. Fractions of the drugs released from the PLA-CL films were governed by the initial loading, the film thickness, and the polymer molecular weight. The drug release profiles obeyed the classical Fickian diffusion equation at least in the early stage, but significant hydrolytic degradation of the matrix polymers occurred in the later stage, influencing the kinetics of drug release. The monomer composition of copolymer affected the release profile more strongly than the initial molecular weight of the copolymer.
引用
收藏
页码:1292 / 1296
页数:5
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