THE 1ST FIELD TRIALS OF THE CHEMICALLY SYNTHESIZED MALARIA VACCINE SPF66 - SAFETY, IMMUNOGENICITY AND PROTECTIVITY

被引:69
作者
AMADOR, R
MORENO, A
VALERO, V
MURILLO, L
MORA, AL
ROJAS, M
ROCHA, C
SALCEDO, M
GUZMAN, F
ESPEJO, F
NUNEZ, F
PATARROYO, ME
机构
[1] FUERZAS MIL, TUMACO, COLOMBIA
[2] UNIV NACL COLOMBIA, BOGOTA, COLOMBIA
关键词
PLASMODIUM-FALCIPARUM; VACCINE; FIELD TRIAL; SAFETY; IMMUNOGENICITY; PROTECTIVITY; PLASMODIUM-VIVAX;
D O I
10.1016/0264-410X(92)90009-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This paper reports the results of the first field study performed to assess the safety, immunogenicity and protectivity of the synthetic malaria vaccine SPf66 directed against the asexual blood stages of Plasmodium falciparum. Clinical and laboratory tests were performed on all volunteers prior to and after each immunization, demonstrating that no detectable alteration was induced by the immunization process. The vaccines were grouped as high, intermediate or low responders according to their antibody titres directed against the SPf66 molecule. Two of the 185 (1.08%) SPf66-vaccinated and nine of the 214 (4.20%) placebo-vaccinated volunteers developed P. falciparum malaria. The efficacy of the vaccine was calculated as 82.3% against P. falciparum and 60.6% against Plasmodium vivax.
引用
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页码:179 / 184
页数:6
相关论文
共 33 条
[1]  
BALLOU WR, 1987, LANCET, V1, P1277
[2]   USE OF SYNTHETIC AND RECOMBINANT PEPTIDES IN THE STUDY OF HOST-PARASITE INTERACTIONS IN THE MALARIAS [J].
CAMPBELL, GH ;
ALEY, SB ;
BALLOU, WR ;
HALL, T ;
HOCKMEYER, WT ;
HOFFMAN, SL ;
HOLLINGDALE, MR ;
HOWARD, RJ ;
LYON, JA ;
NARDIN, EH ;
NUSSENZWEIG, RS ;
NUSSENZWEIG, V ;
TSANG, VCW ;
WEBER, JL ;
WELLEMS, TE ;
YOUNG, JF ;
ZAVALA, F .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1987, 37 (03) :428-444
[3]   2 APPARENTLY NON-REPEATED EPITOPES ON GAMETES OF PLASMODIUM-FALCIPARUM ARE TARGETS OF TRANSMISSION-BLOCKING ANTIBODIES [J].
CARTER, R ;
BUSHELL, G ;
SAUL, A ;
GRAVES, PM ;
KIDSON, C .
INFECTION AND IMMUNITY, 1985, 50 (01) :102-106
[4]   IMMUNIZATION WITH SYNTHETIC PEPTIDES OF A PLASMODIUM-FALCIPARUM SURFACE-ANTIGEN INDUCES ANTIMEROZOITE ANTIBODIES [J].
CHEUNG, A ;
LEBAN, J ;
SHAW, AR ;
MERKLI, B ;
STOCKER, J ;
CHIZZOLINI, C ;
SANDER, C ;
PERRIN, LH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8328-8332
[5]   IMMUNIZATION OF MAN AGAINST FALCIPARUM AND VIVAX MALARIA BY USE OF ATTENUATED SPOROZOITES [J].
CLYDE, DF ;
MCCARTHY, VC ;
MILLER, RM ;
WOODWARD, WE .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1975, 24 (03) :397-401
[6]   IMMUNIZATION OF AOTUS MONKEYS WITH RECOMBINANT PROTEINS OF AN ERYTHROCYTE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM [J].
COLLINS, WE ;
ANDERS, RF ;
PAPPAIOANOU, M ;
CAMPBELL, GH ;
BROWN, GV ;
KEMP, DJ ;
COPPEL, RL ;
SKINNER, JC ;
ANDRYSIAK, PM ;
FAVALORO, JM ;
CORCORAN, LM ;
BRODERSON, JR ;
MITCHELL, GF ;
CAMPBELL, CC .
NATURE, 1986, 323 (6085) :259-262
[7]   PRIMARY STRUCTURE OF THE MEROZOITE SURFACE ANTIGEN-1 OF PLASMODIUM-VIVAX REVEALS SEQUENCES CONSERVED BETWEEN DIFFERENT PLASMODIUM SPECIES [J].
DELPORTILLO, HA ;
LONGACRE, S ;
KHOURI, E ;
DAVID, PH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :4030-4034
[8]  
FREUND J, 1948, AM J TROP MED, V28, P1
[9]   GENETIC-CONTROL OF THE IMMUNE-RESPONSE IN MICE TO A PLASMODIUM-FALCIPARUM SPOROZOITE VACCINE - WIDESPREAD NONRESPONSIVENESS TO SINGLE MALARIA T-EPITOPE IN HIGHLY REPETITIVE VACCINE [J].
GOOD, MF ;
BERZOFSKY, JA ;
MALOY, WL ;
HAYASHI, Y ;
FUJII, N ;
HOCKMEYER, WT ;
MILLER, LH .
JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (02) :655-660
[10]  
GRUMET CF, 1972, J EXP MED, V135, P110