HIGH-RESOLUTION CHROMOSOMAL LOCALIZATION OF THE HUMAN CALCITONIN CGRP/IAPP GENE FAMILY MEMBERS

被引：35

作者：

HOOVERS, JMN

REDEKER, E

SPELEMAN, F

HOPPENER, JWM

BHOLA, S

BLIEK, J

VANROY, N

LESCHOT, NJ

WESTERVELD, A

MANNENS, M

机构：

[1] STATE UNIV GHENT HOSP, DEPT MED GENET, B-9000 GHENT, BELGIUM

[2] UNIV UTRECHT, INST MOLEC BIOL & MED BIOTECHNOL, UTRECHT, NETHERLANDS

来源：

GENOMICS | 1993年 / 15卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1104

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the high-resolution localization of the human calcitonin/CGRP genes, CALCA, CALCB, and the pseudogene CALCP, to a 220-kb SacII fragment on chromosome 11p15.2p-p15.1, using prometaphase fluorescence in situ hybridization (FISH), two-color interphase FISH, and pulsed-field gel electrophoresis analysis. The related islet amyloid polypeptide (IAPP) gene was assigned to human chromosome 12pl2.3-p12.1. The results support an evolutionary relationship between the calcitonin/CGRP genes and the IAPP gene and between parts of human chromosomes 11 and 12. © 1993 by Academic Press, Inc.

引用

页码：525 / 529

页数：5

共 35 条

[1] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS [J].