SYNTHESIS AND SPECTROSCOPY STUDIES OF COPPER(II) NITRATE OF SULFACETAMIDE DRUG - CRYSTAL-STRUCTURE OF [CU(SULFACETAMIDE)(2)(NO3)(2)] - ANTIBACTERIAL STUDIES

The structural spectroscopic, and thermal properties of a complex of sulfacetamide (Hsacm) with Cu(II) have been investigated. The complex [Cu(Hsacm)(2)(NO3)(2)] crystallizes in the monoclinic system, space group P2(1)/n. The cell dimensions are a = 7.696(7) Angstrom, b = 8.017(7) Angstrom, c = 19.230(10), beta = 110.80(1)degrees, V = 1109(1)Angstrom(3), Z = 2, and D-x = 1.84 g/cm(3). The structure was refined to R = 0.0776. Cu(Hsacm)(2)(NO3)(2) molecules form a long polymeric chain extended along the b-axis. The copper(II) coordinated geometry is tetragonally distorted octahedral with two amino nitrogens from Hsacm and two oxygens from nitrate anions in the basal plane and two acetamido oxygens from neighbor Hsacm molecules in the apical position. Each sulfacetamide, acting as a bidentate ligand, links two Cu(II) ions as a bridge through the N-amino and the O-acetamido atoms. The complex proved to possess higher bacteriostatic activity than the corresponding ligand.