INTELLIGENT POLYMERS IN MEDICINE AND BIOTECHNOLOGY

被引:140
作者
HOFFMAN, AS
机构
[1] Center for Bioengineering, University of Washington, Seattle, Washington
关键词
INTELLIGENT POLYMERS; BIOMOLECULES; TEMPERATURE-SENSITIVE POLYMERS; COPOLYMERS; POLYMER-PROTEIN CONJUGATES; HYDROGELS;
D O I
10.1111/j.1525-1594.1995.tb02359.x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
One can define ''intelligent'' polymers as those polymers that respond with large property changes to small physical or chemical stimuli. These polymers may be in various forms, such as in solution, on surfaces, or as solids. One may also combine intelligent aqueous polymer systems with biomolecules to yield a large family of polymers that respond intelligently to physical, chemical, or biological stimuli. This article overviews such interesting and versatile polymer systems.
引用
收藏
页码:458 / 467
页数:10
相关论文
共 59 条
[1]  
ALBIN G, 1985, Journal of Controlled Release, V2, P153, DOI 10.1016/0168-3659(85)90041-0
[2]  
BAE YH, 1987, MAKROMOL CHEM-RAPID, V8, P481
[3]   PREPARATION AND PROPERTIES OF THERMOREVERSIBLE, PHASE-SEPARATING ENZYME-OLIGO(N-ISOPROPYLACRYLAMIDE) CONJUGATES [J].
CHEN, GH ;
HOFFMAN, AS .
BIOCONJUGATE CHEMISTRY, 1993, 4 (06) :509-514
[4]   GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].
CHEN, GH ;
HOFFMAN, AS .
NATURE, 1995, 373 (6509) :49-52
[5]  
CHEN GH, IN PRESS MACROMOL RA
[6]   POLYMER PROTEIN CONJUGATES .2. AFFINITY PRECIPITATION SEPARATION OF HUMAN IMMUNO-GAMMA-GLOBULIN BY A POLY(N-ISOPROPYLACRYLAMIDE)-PROTEIN-A CONJUGATE [J].
CHEN, JP ;
HOFFMAN, AS .
BIOMATERIALS, 1990, 11 (09) :631-634
[7]   GELS AS SIZE SELECTIVE EXTRACTION SOLVENTS [J].
CUSSLER, EL ;
STOKAR, MR ;
VARBERG, JE .
AICHE JOURNAL, 1984, 30 (04) :578-582
[8]  
De Rossi D, 1991, POLYM GELS
[9]  
DEGENNES PG, 1972, PHYS LETT, V339, pA38
[10]  
DONG LC, 1992, J CONTROL RELEASE, V19, P171