GROWTH-HORMONE RELEASE INHIBITORY HORMONE-LIKE IMMUNOREACTIVITY IN PANCREAS AND GUT IN STREPTOZOTOCIN DIABETES IN THE RAT AND RESPONSE TO INSULIN ADMINISTRATION

被引：27

作者：

BERELOWITZ, M ^{[1
]}

SHAPIRO, B ^{[1
]}

PIMSTONE, B ^{[1
]}

KRONHEIM, S ^{[1
]}

机构：

[1] UNIV CAPE TOWN,DEPT MED,ISOTOPE & IMMUNOASSAY LAB,CAPE TOWN 7900,SOUTH AFRICA

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 02期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb01366.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In streptozotocin diabetes in the rat, growth hormone release‐inhibitory hormone‐like immunoreactivity (GHRIH‐LI) content of pancreas, gastric antrum and colon was increased. Insulin therapy significantly lowered the increased pancreatic GHRIH‐LI content but did not affect that of the gastric antrum and colon at the dosage used. The relevance of these findings in relation to pancreatic and gastrointestinal function in diabetes awaits clarification. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：195 / 198

页数：4

共 18 条

[1] STIMULATION OF GLUCAGON-RELEASE BY ADDITION OF ANTI-SOMATOSTATIN SERUM TO ISLETS OF LANGERHANS INVITRO
BARDEN, N
LAVOIE, M
DUPONT, A
COTE, J
COTE, JP
[J]. ENDOCRINOLOGY, 1977, 101 (02) : 635 - 638
[2] BLOOM SR, 1975, GUT, V16, P834
[3] REGIONAL DISTRIBUTION OF SOMATOSTATIN IN RAT-BRAIN
BROWNSTEIN, M
ARIMURA, A
SATO, H
SCHALLY, AV
KIZER, JS
[J]. ENDOCRINOLOGY, 1975, 96 (06) : 1456 - 1461
[4] IMMUNOREACTIVE SOMATOSTATIN IS PRESENT IN DISCRETE CELLS OF ENDOCRINE PANCREAS
DUBOIS, MP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (04) : 1340 - 1343
[5] LONG-TERM CHANGES OF ALPHA1 AND ALPHA2 CELLS IN ISLETS OF LANGERHANS OF RATS WITH ALLOXAN DIABETES
HELLMAN, B
PETERSSON, B
[J]. ENDOCRINOLOGY, 1963, 72 (02) : 238 - &
[6] SOMATOSTATIN - HYPOTHALAMIC INHIBITOR OF ENDOCRINE PANCREAS
KOERKER, DJ
RUCH, W
CHIDECKEL, E
PALMER, J
GOODNER, CJ
ENSINCK, J
GALE, CC
[J]. SCIENCE, 1974, 184 (4135) : 482 - 484
[7] RADIOIMMUNOASSAY FOR GROWTH-HORMONE RELEASE-INHIBITING HORMONE - METHOD AND QUANTITATIVE TISSUE DISTRIBUTION
KRONHEIM, S
BERELOWITZ, M
PIMSTONE, BL
[J]. CLINICAL ENDOCRINOLOGY, 1976, 5 (06) : 619 - 630
[8] FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS
ORCI, L
UNGER, RH
[J]. LANCET, 1975, 2 (7947) : 1243 - 1244
[9] HYPERTROPHY AND HYPERPLASIA OF SOMATOSTATIN-CONTAINING D-CELLS IN DIABETES
ORCI, L
BAETENS, D
RUFENER, C
AMHERDT, M
RAVAZZOLA, M
STUDER, P
MALAISSELAGAE, F
UNGER, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (04) : 1338 - 1342
[10] PATEL YC, 1977, SCIENCE, V198, P930, DOI 10.1126/science.337488

← 1 2 →