NEAR QUANTITATIVE PRODUCTION OF MOLECULAR NITROGEN FROM METABOLISM OF DIMETHYLNITROSAMINE

被引：21

作者：

MILSTEIN, S

GUTTENPLAN, JB

机构：

[1] Department of Biochemistry New York University Dental Center New York

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91684-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N2 is produced stoichiometrically from the spontaneous decomposition of N-methyl-N-nitrosourea in phosphate buffer and is readily detected by gas chromatography. It is also generated in high yield from the oxidation of dimethylnitrosamine [a carcinogen, mutagen and hepatotoxin] by mouse or rat liver microsomes. Gas chromatographic analysis for N generated from dimethylnitrosamine was more difficult because the amount of N generated was similar to that produced in control tubes which contained no dimethylnitrosamine.

引用

页码：337 / 342

页数：6

共 17 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].