LOCALIZATION OF A GENE FOR THE HUMAN LOW-VOLTAGE EEG ON 20Q AND GENETIC-HETEROGENEITY

被引：79

作者：

STEINLEIN, O

ANOKHIN, A

YPING, M

SCHALT, E

VOGEL, F

机构：

[1] Institute of Human Genetics, University of Heidelberg

来源：

GENOMICS | 1992年 / 12卷 / 01期

关键词：

D O I：

10.1016/0888-7543(92)90408-K

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The localization of a gene responsible for a normal variant of the human electroencephalogram to the distal part of chromosome 20q is reported. A linkage analysis, including 17 families with 191 individuals, tested with 73 RFLPs and 22 blood and serological markers, was performed for the low-voltage electroencephalogram. This is a normal variant of the human electroencephalogram with an autosomal dominant mode of inheritance. The results present strong evidence for close linkage with the highly polymorphic marker CMM6 (D20S19) and for genetic heterogeneity. © 1992.

引用

页码：69 / 73

页数：5

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