STRUCTURAL REMODELING OF CARDIAC MYOCYTES IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY

被引:241
作者
GERDES, AM
KELLERMAN, SE
MOORE, JA
MUFFLY, KE
CLARK, LC
REAVES, PY
MALEC, KB
MCKEOWN, PP
SCHOCKEN, DD
机构
[1] TAMPA GEN HOSP, CARDIAC INST FLORIDA, TAMPA, FL 33606 USA
[2] UNIV S FLORIDA, COLL MED, DEPT INTERNAL MED, DIV CARDIOL, TAMPA, FL 33612 USA
[3] UNIV S FLORIDA, COLL MED, DEPT SURG, TAMPA, FL 33612 USA
关键词
MYOCYTES; MYOCARDIUM; HUMAN; HEART FAILURE;
D O I
10.1161/01.CIR.86.2.426
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Chronic ischemic heart disease may lead to ventricular dilation and congestive heart failure (ischemic cardiomyopathy [ICM]). The changes in cardiac myocyte shape associated with this dilation, however, are not known. Methods and Results. Left ventricular myocyte dimensions were assessed in cells isolated from explanted human hearts obtained from patients with ICM (n=6) who were undergoing heart transplantation. Cells were also examined from three nonfailing donor hearts with normal coronary arteries (NCA). Compared with cells from patients with NCA, myocyte length was 40% longer in hearts from patients with ICM (197+/-8 versus 141+/-9-mu-m, p<0.01), cell width was not significantly different, and cell length/width ratio was 49% greater (11.2+/-0.9 versus 7.5+/-0.6, p<0.01). Sarcomere length was the same in myocytes from both groups. The extent of myocyte lengthening is comparable to the increase in end-diastolic diameter commonly reported in patients with ICM. Conclusions. These data suggest that increased myocyte length (an intracellular event), instead of myocyte slippage (an extracellular event), is largely responsible for the chamber dilation in ICM. Furthermore, maladaptive remodeling of myocyte shape (e.g., increased myocyte length/width ratio) may contribute to the elevated wall stress (e.g., increased chamber radius/wall thickness) in ICM.
引用
收藏
页码:426 / 430
页数:5
相关论文
共 19 条
  • [1] INFLUENCE OF AGE, GROWTH, AND SEX ON CARDIAC MYOCYTE SIZE AND NUMBER IN RATS
    BAI, SL
    CAMPBELL, SE
    MOORE, JA
    MORALES, MC
    GERDES, AM
    [J]. ANATOMICAL RECORD, 1990, 226 (02): : 207 - 212
  • [2] SURFACE-MORPHOLOGY AND CELL-SIZE MEASUREMENT OF ISOLATED RAT CARDIAC MYOCYTES
    BISHOP, SP
    DRUMMOND, JL
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1979, 11 (05) : 423 - +
  • [3] ISCHEMIC CARDIOMYOPATHY
    BURCH, GE
    TSUI, CY
    HARB, JM
    [J]. AMERICAN HEART JOURNAL, 1972, 83 (03) : 340 - &
  • [4] COMPARISON OF REGIONAL DIFFERENCES IN CARDIAC MYOCYTE DIMENSIONS IN RATS, HAMSTERS, AND GUINEA-PIGS
    CAMPBELL, SE
    GERDES, AM
    SMITH, TD
    [J]. ANATOMICAL RECORD, 1987, 219 (01): : 53 - 59
  • [5] EFFECT OF VASODILATOR THERAPY ON MORTALITY IN CHRONIC CONGESTIVE-HEART-FAILURE - RESULTS OF A VETERANS-ADMINISTRATION COOPERATIVE STUDY
    COHN, JN
    ARCHIBALD, DG
    ZIESCHE, S
    FRANCIOSA, JA
    HARSTON, WE
    TRISTANI, FE
    DUNKMAN, WB
    JACOBS, W
    FRANCIS, GS
    FLOHR, KH
    GOLDMAN, S
    COBB, FR
    SHAH, PM
    SAUNDERS, R
    FLETCHER, RD
    LOEB, HS
    HUGHES, VC
    BAKER, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (24) : 1547 - 1552
  • [6] ECHOCARDIOGRAPHIC FEATURES OF CONGESTIVE CARDIOMYOPATHY COMPARED WITH CORONARY-ARTERY DISEASE
    CORYA, BC
    FEIGENBA.H
    RASMUSSE.S
    BLACK, MJ
    [J]. CIRCULATION, 1974, 49 (06) : 1153 - 1159
  • [7] GERDES AM, 1982, LAB INVEST, V46, P271
  • [8] REGIONAL DIFFERENCES IN MYOCYTE SIZE IN NORMAL RAT-HEART
    GERDES, AM
    MOORE, JA
    HINES, JM
    KIRKLAND, PA
    BISHOP, SP
    [J]. ANATOMICAL RECORD, 1986, 215 (04): : 420 - 426
  • [9] WALL STRESS AND PATTERNS OF HYPERTROPHY IN HUMAN LEFT-VENTRICLE
    GROSSMAN, W
    JONES, D
    MCLAURIN, LP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (01) : 56 - 64
  • [10] REGIONAL INCREASE IN ISOLATED MYOCYTE VOLUME IN CHRONIC MYOCARDIAL-INFARCTION IN CATS
    KOZLOVSKIS, PL
    GERDES, AM
    SMETS, M
    MOORE, JA
    BASSETT, AL
    MYERBURG, RJ
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1991, 23 (12) : 1459 - 1466